EMERGENCY TREATMENT OF POISONING

GENERAL CARE

It is often impossible to establish with certainty the identity of the poison and the size of the dose. Fortunately this is not usually important because only a few poisons have specific antidotes. In most patients, treatment is directed at managing symptoms as they arise.

• RESPIRATION

Most poisons that impair consciousness also depress respiration. Assisted ventilation may be needed. Oxygen is not a substitute for adequate ventilation, although it should be given in the highest concentration possible in poisoning with carbon monoxide and irritant gases.

Respiratory stimulants so not help and should be avoided.

• BLOOD PRESSURE

Hypotension is common in severe poisoning with central nervous system depressants. A systolic blood pressure of less than 70mmHg may lead to irreversible brain damage or renal tubular necrosis.

Hypotension should be corrected initially by tilting down the head of the bed and administration of either sodium chloride  intravenous infusion or a colloidal infusion.

Hypertension, often transient, occurs less frequently and it may be associated with sympathomimetic drugs such as amphetamines, phencyclidine and cocaine.

• HEART

Cardiac conduction defects and arrhythmias can occue in acute poisoning, notably with tricyclic antidepressants , some antipsychotics, and some antihistamines.

• BODY TEMPERATURE

Hypothermia may develop in patients of any age who have been deeply unconscious for some hours, particularly following overdose with barbiturates or phenothiazines.

Hyperthermia can develop in patients taking CNS stimulants, children and the elderly are also at risk when taking therapeutic doses of drugs with antimuscarinic properties.

Both hypothermia and hyperthermia require urgent hospitalisation.

• CONVULSIONS

Single short -lived convulsions do not require treatment. If convulsions are protracted or recur frequently, lorazepam (4mg) or diazepam (10mg) should be given by slow intravenous injection into a large vein, diazepam can be administered as a rectal solution or midazolam can be given by the buccal route.

REMOVAL AND ELIMINATION

• Prevention of absorption

Given by mouth, activated charcoal can bind many poisons in the gastro-intestinal system, thereby reducing their absorption. The sooner it is given the more effective it is, but it may still be effective  up to 1 hour after ingestion of the poison.

• Active elimination techniques

Repeated doses of activated charcoal by mouth enhance the elimination of some drugs after they have been absorbed, repeated doses are given after overdosage with:

-Carbamazepine

-Dapsone

-Phenobarbital

-Quinine

-Theophylline

The usual dose of activated charcoal in adults and children over 12 years of age is 50g initially then 50g every 4 hours. Vomiting should be treated since it may reduce the efficacy of charcoal treatment.In cases of intolerance, the dose may be reduced and the frequency increased.

Other techniques intended to enhance the elimination of poisons after absorption:

-Hemodialysis for salicylates, phenobarbital, methyl alcohol (methanol), ethylene glycol and lithium.

-Alkalinisation of the urine for salicylates and phenoxyacetate herbicides.

• Removal from gastro-intestinal tract

Gastric lavage is rarely required, it should be considered only if a life-threatening amount has been ingested within the previous hour and the airway can be protected adequately.

It may occasionally be considered in patients who have ingested drugs that are not absorbed by charcoal, such as iron or lithium.

Whole bowel irrigation has been used in poisoning with certain modified-release or enteric coated formulations, in severe poisoning  with iron or lithium salts and if illicit drugs are carried in the gastro-intestinal tract.

SPECIFIC DRUGS

 More information: http://www.toxbase.org/
Source: BNF (British National Formulary) 2009

ACCIDENT FORM

Falls can be a serious problem in the hospital or in a nursing home. They may be caused by:

• Poor lighting, slippery floors, and equipment in rooms and hallways that gets in the way
• Being weak from illness or surgery and being in new surroundings

Hospital staff often do not see patients fall. But falls require attention right away to lessen the risk of injury.

When the Patient Falls

If you are with a patient when they begin to fall:

• Use your body to break their fall.
• Protect your own back by keeping your feet wide apart and your knees bent.
• Make sure the patient’s head does not hit the floor or any furniture.

AFTER THE FALL

Stay with the patient and call for help.

• Check the patient’s breathing, pulse, and blood pressure. If the patient is unconscious, not breathing, or does not have a pulse, call a hospital emergency code.
• Check for injury, such as cuts, scrapes, bruises, and broken bones.
• If you were not there when the patient fell, ask the patient or someone who saw the fall what happened.

If the patient is confused, shaking, or shows signs of weakness, pain, or dizziness:

• Stay with the patient. Provide blankets for comfort until medical staff can evaluate them.
• Do not raise the patient’s head if they may have injured their neck or back. Wait for medical staff to check for a spinal injury.

Once medical staff decides the patient can be moved, you need to choose the best way to move them.

• If the patient is not hurt or injured and does not appear ill, have another staff member help you. Both of you should help the patient into a wheelchair or their bed. Do not help them on your own.
• If they cannot support most of their own body weight, you may need to use a backboard or a lift.

Watch the patient closely after their fall. You may need to check their alertness, their blood pressure and pulse, and perhaps their blood sugar.

Document the fall according to your hospital’s policies.

EXAMPLE OF ACCIDENT FORM:

Source: Medline Plus.